Cilostazol for Intermittent Claudication
نویسندگان
چکیده
A review of the Cochrane Vascular Specialized Register, CENTRAL, MEDLINE, Embase, CINAHL, and AMED databases, World Health Organization International Clinical Trials Registry Platform ClinicalTrials.gov trials registries on November 9, 2020. Participants taking cilostazol had higher initial claudication distance absolute compared with those placebo, along a possible improvement quality life (16 double-blind, randomized controlled trials). There was no difference detected between pentoxifylline for improving or (5 The most commonly reported adverse events were headache, gastrointestinal symptoms, palpitations. Cilostazol has been shown to improve walking in people intermittent claudication, but there distance. odds experiencing headache.
منابع مشابه
Cilostazol Has Beneficial Effects in Treatment of Intermittent Claudication
Background—Cilostazol is a new phosphodiesterase inhibitor that suppresses platelet aggregation and also acts as a direct arterial vasodilator. This prospective, randomized, placebo-controlled, parallel-group clinical trial evaluated the efficacy of cilostazol for treatment of stable, moderately severe intermittent claudication. Methods and Results—Study inclusion criteria included age $40 year...
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BACKGROUND Intermittent claudication (IC) is a symptom of peripheral arterial disease (PAD) and is associated with high morbidity and mortality. Pentoxifylline, one of many drugs used to treat IC, acts by decreasing blood viscosity, improving erythrocyte flexibility and promoting microcirculatory flow and tissue oxygen concentration. Many studies have evaluated the efficacy of pentoxifylline in...
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OBJECTIVES The purpose of this study was to investigate whether cilostazol reduces restenosis and revascularization after endovascular therapy (EVT) for femoropopliteal lesions. BACKGROUND Cilostazol improves walking distance in patients with intermittent claudication and reduces restenosis after coronary intervention, but its efficacy remains unclear after EVT for femoropopliteal disease. ...
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BACKGROUND Intermittent claudication (IC) is pain caused by chronic occlusive arterial disease, that develops in a limb during exercise and is relieved with rest. Buflomedil is a vasoactive agent used to treat peripheral vascular disease. However, its clinical efficacy for IC has not yet been critically examined. This is an update of a Cochrane review first published in 2000, and previously upd...
متن کاملIntermittent claudication
Peripheral arterial disease is a common health problem that globally affects over 200 million individuals, and intermittent claudication (IC) is the most common symptomatic presentation. The leg symptoms in IC are provoked by walking exercise and can be alleviated by medical intervention, exercise training and invasive vascular interventions (revascularization). The quality of evidence for inva...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2021
ISSN: ['1085-875X', '0741-5214', '1097-6809']
DOI: https://doi.org/10.1016/j.jvs.2021.07.118